Watch Sheryl Sandberg Interview Priscilla Chan At Fortune's MPW Summit | Fortune Most Powerful Women
11 Video Views·Jan 16, 2026
Watch Priscilla Chan's full panel with Sheryl Sandberg.
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So I have been fortunate to attend this conference
for many, many years, and it has been important to me
in my career.
And there is nothing like walking into this room
with all of these women.
Feels just like the rest of our days, right?
Just like another day in the office.
Anyway, really excited to be here,
and even more excited to introduce this audience
to one of the most special people I know,
brilliant philanthropist and a really dear friend.
So Priscilla, you and Mark, obviously,
almost a year ago, Max is about to turn a year,
started CVI.
And that is, as Nina said,
a tremendous commitment to philanthropy,
but also one you're doing far younger in life
than you look at any other philanthropist like you.
Why were you inspired to make public service
so central in your life?
And why take that step at this stage,
which again, is very, very unusual.
Well, this work is incredibly important in personal living.
I am the daughter of Chinese Vietnamese refugees
who came to this country with nothing
and believed in the power of education
to make sure that me and my sisters
had a chance at really succeeding in life.
And my teachers in public school carried me there.
They paved the way for me to arrive at Harvard,
where I realized that I had reached a place
of incredible opportunity
that not many other children who were in circumstances
like mine have a chance of really accessing.
And it was at that moment that I realized
that I was gonna make public service central in my life.
So right there in college,
I began running an afterschool program
where I helped, in name, we were supposed to help
children living in a low-income housing project
with their homework.
In reality, we did whatever we needed to do
to help those children thrive.
Helped with work at home,
things going on at home, homework, health, everything.
And it was in that work
that I had a really important experience in my life.
One of my students was absent for a couple days,
and someone from the school came to see me
to help find that student.
And I agreed to and walked out to the play yard
after program that day, and I found her.
And she immediately looked at me
and started answering why she hadn't been to school.
And I saw immediately why.
The two front seats were broken,
and I was, I just flooded with questions.
What happened?
Did someone hurt her?
What could I have done to prevent this from happening?
And it's that question that drives all of my work.
It's a really complicated question,
and I certainly didn't have the tools at 21 to solve it,
and that's why in that moment,
I decided to go to medical school
to learn more about how I could advocate
for the lives and health of children.
And now, the potential for our work
is really thinking about how we learn more
about keeping children healthy,
and how do we build systems and empower people
to keep children engaged and learning in the classroom?
Those are incredibly challenging questions,
and hard to really even get your mind around and understand.
And so, it's incredibly important
that Mark and I invest now,
that we take risks in making big, important investments
that may take 25, 50, 100 years to pan out.
But during that time, starting now,
Mark and I can really take advantage of the opportunity
to learn and to get better,
to really optimize our chances
of actually making an impact.
You have, yeah, took some of these early experiences,
and this year, you opened up a school in East Palo Alto,
and the school has a really unusual goal,
which is you're not trying to provide just education,
but you're trying to provide health care,
and that clearly comes right from the experience
that we're talking about.
Talk to us about what the school is doing,
what its goals are, and how you're trying to do those,
and why that's important.
Yeah, the school is really a continuation
of my work as a pediatrician.
I went to medical school and have been practicing
as a primary care pediatrician
at our county safety net hospital for the past five years.
And when I began my practice, I said,
I am gonna be a pediatrician that really thinks about
and understands a child's educational trajectory
and how to set them up for success
from the health standpoint,
so that they can be present and ready to learn.
And I was diligent, I asked the questions,
I wrote down the answers to my questions,
and a couple years in, I encountered a patient
where, I can tell you, I literally failed.
I was taking care of a second grader
who was coming to me with acute problems,
really struggling in school, and a seizure disorder.
And the story didn't really quite fit,
so I spent many visits over the course of the year
helping untap what was going on.
And what I realized after that year
was that this child did not have a seizure disorder.
This child had been exposed to extreme trauma at home,
and what manifested was a behavioral problem
that made it so that the school and the mom
excused his participation in school
under the guise of seizure disorder.
So this child missed 150 days of school, nearly a year,
because of the lack of communication
between school and health providers,
and also lack of empowerment of the mother
to really make sure that the kid,
she had what she needed to allow the kid to proceed.
And I've missed that as a pediatrician who tried herself
in really thinking about health and education
through the same lens.
And so the primary school's goal
is to really bring together
these really incredibly important systems,
health and education, to work together
to improve the lives of the kids
who need these systems to work the most.
And we're nine weeks old, so there's a lot to learn,
but that's our vision of what we can hopefully accomplish
in the next, the decades to come.
You've been a teacher, you've been a doctor,
you're now running a school.
Mark's a technologist.
And when you launched UCI, you laid out your priorities.
I'd love for you to share with the audience
what those priorities were,
and how your experience as a teacher and doctor,
Mark's as a technologist, have informed those priorities.
Yeah.
Running a school's not enough.
That's just one of the things here.
What we've learned so far is that Mark and I
can make the biggest impact
when we not only invest our resources,
but we also bring our expertise and passion
to the table to solve problems as well.
And like you said, Mark's a computer engineer,
and so he's got, along with you,
a lot of experience building tools and scaling them.
That would be mostly him talking, but.
Thank you.
It's a partnership.
She's always really generous.
And for me, I have the experience of bringing the lens
of being a pediatrician and an educator
to really understand the different problems
that we're tackling.
And that together really has enriched
both our understanding of the problems
that we're trying to solve,
and the additional insight
and being part of building the solution
that Mark and I can really participate in.
And I'll give you an example.
We're building a tool for personalized learning.
And so Mark has really been engaged
in thinking about how can we build the best tool possible
to allow these students to have an incredible resource
to really drive and own their education.
And the kids are very critical.
They give feedback on how the tool isn't working.
And that's really,
he and the team are working hard on it.
But for me, I think about how is this tool
gonna engage students?
How is this tool gonna engage families?
How is this tool gonna empower teachers
to be even better at their work?
And so that's how we bring ourselves
as practitioners to the work.
And that work rounds us in helping us understand
and keep laser focused on what's the most important thing
in what we do.
Great.
So not a lot of people work with the person they're married to.
Raise your hand if you are working
with a partner of some kind.
How does this partnership work for you and Mark?
Well, it starts with lots of phone calls to you.
His other partner.
But in all honesty, it's really fun.
And we have a lot to learn from each other.
We really, we are complimentary and we drive each other
to really, we challenge each other to think more deeply
about the questions that we're faced with.
Whether Mark is asking me questions
to keep me laser focused on what our goals are.
If we're really making decisions that advance our goal
or whether or not we are deviating from the mission
that we've set out for ourselves.
And for me, I force him to learn more
about what's the context?
What are we trying to do?
Who are the people involved?
What are the cultures that we're trying to work with?
And how can we learn more from the people
already doing the work?
And so we push each other in different ways.
It can be uncomfortable at times, but it's really fun.
One of the ways you've pushed each other
and I think challenged everyone
is you just recently announced KPI Science.
And with a really big audacious poll, talk about that.
Yeah, we've spent the past two years
talking to scientists all over the world,
all different levels of training,
post-graduates to Nobel Prize laureates.
And really trying to learn, how can we help?
How can we make your work even better?
And what we've heard is really a need
for tools and technology.
I think for those not in health or science,
it may not be obvious,
but the tools and access to technology
that you have to make your lives and your work better
are not available to one of the most important sectors
that we have, health and science.
That big gap makes it difficult for the scientists
to really be able to ask the next level of question
and really innovative and creative inquiry
about the work that they're studying,
about the human body.
And so after hearing that
and hearing about the tools that they're asking for,
we decided that is a great match
for what we're able to bring.
We just announced the hire of our CTO
at the Chan Zuckerberg Initiative.
And he's gonna build a world-class engineering team
to make sure that we bring the highest quality tools
and technologies to the people
who are gonna make the discoveries
that change the way all of us live and stay healthy.
Pretty amazing.
Got a big gasp from the audience.
So you're, as you said,
the first college graduate in your family.
And I've certainly seen how you've taken your experience.
I've watched the advice you've given my children
as they've grown over the past eight years.
We're at a conference for women.
This is a lean-in crowd.
These women have leaned in hard in lots of ways
to support themselves, support their families,
and get into this room.
What's your advice for women and girls out there
on how to lean in?
I think the most important piece of advice
that I've heard from you as well,
encouraging all women to lean in,
is you, and I have to remind myself of this,
you are capable beyond your wildest imagination.
And whatever you wanna do, do it now.
There's gonna be a village to help support you,
the village.
And it will be great.
All right, we're gonna do a quick lightning round for fun,
and then we'll probably have time
for an audience question or two.
All right, who's your real-life heroine?
Well, you've got me started on this.
My real-life heroine is Ruth Bader Ginsburg.
She blazed the trail.
What is the book that changed your perspective on it?
There's this book called Far From the Tree.
It's by Andrew Solomon.
It's about parents who raise children
who are fundamentally different from them,
whether or not their child is a genius or deaf
or have severe physical disabilities.
It talks about the experience of parents and those children,
and that book really helped me relate to the parents
and the families that I take care of as a teenager.
Mark's favorite thing to cook for you?
Okay, Mark cooks, and this is all one unit.
You can't have less or more or any different.
He cooks two racks of baby back ribs,
and that's the Mark special.
It's true.
Actually, very early, Priscilla and I were talking about this.
Very early in my tenure at Facebook,
there was one weekend where Priscilla was out of town,
and Dave was out of town, so Mark and I looked at each other.
We're like, what are you doing tomorrow?
I'm like, I have no plans.
You have no plans.
He's like, come over for dinner,
and so Mark made me meat, like literally.
He started the grill, and he cooked for the two of us
like this much steak, and there was nothing else.
There was just this much steak,
and then he took it off, and he did it himself,
and it was completely delicious.
It's just I wasn't used to having a meal of all-meat steak.
I was kind of, and you know, he's my new boss.
I didn't want to insult him.
I was kind of looking around for the salad,
anything else, it wasn't there,
but the steak was delicious.
Do you cook for him?
Rarely, but when we're tired of the all-meat diet,
I jump in a little bit.
Who are you more excited to dress up
for Halloween, Max or Beast?
Well, it's gonna be.
People love Beast.
Beast is dog famous.
We're doing a whole family costume,
so I think the person I'm most excited
to see me dressed up is Mark.
All right, we look forward to seeing it
on Facebook and Instagram.
Did you have a favorite class or something
in medical school?
This is kind of a fun story.
I had this one lecture in medical school
that I remember very vividly.
It was led by a man at UCSF called Joe DeRisi,
and he was so energetic, so enthusiastic
about this work, and his work that he was describing
was so out of this world that it sounded
like science fiction, and I was just enthralled
by his lecture and tracked him and his career
over the next decade or so, and when it came time
to found the Biohub, this new institute
that we are building in the Bay Area
where we bring together engineers, scientists,
physicians to really solve hard problems
about human health, his name came up again,
and now he's leading the Biohub,
so you never know when you're really gonna make
an incredibly strong impression and impact on someone.
All right, and this is breaking news
because it just happened.
Max's first word.
Yes, this is really exciting.
So Max's first word, I think influenced
by beasts in our lives, is dog.
That's right, and we, I think she has a second word
for plane, it doesn't sound anything like plane,
but she says it consistently, but that's not,
it has not yet passed Mark's bar of qualifying as a word.
All right, we have like less than one minute left,
maybe we can grab one question from the audience.
We're under very strict instructions to be on time, yeah.
Hi there, Lee Morgan with the Gates Foundation.
I have one question for you, Priscilla.
What do you like best and least
about the philanthropic sector?
I am completely moved by people's dedication
and inspiration for their work.
Everyone is working towards a similar awe-inspiring goal
of how do we make the world and people's lives better?
One point of frustration that I think we can all
really grow from, because I think there's a lot of focus
on it right now, is how can we be more evidence
and data-driven?
How can we actually find ways to hold ourselves
accountable for the work that we're doing?
Okay, Priscilla Chan.
Woo!

